CIN1 期患者基数远超 CIN2 期，其中约 10% 的患者因病变持续进展需要积极干预。目前该领域缺乏针对性非手术治疗方案，难以实现 “早干预” 的临床目标；CIN3 期属于高级别病变，当前以手术治疗为主，但我国 CIN3 患者中 HPV 感染率高达 84.37%，部分无法耐受手术、高龄或有生育需求的患者，存在强烈的无创治疗诉求，亟需匹配 “低损伤” 的治疗方案。
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If Coruna is, in fact, a US hacking toolkit gone rogue, just how it got into foreign and criminal hands remains a mystery. But Cole points to the industry of brokers that may pay tens of millions of dollars for zero-day hacking techniques that they can resell for espionage, cybercrime, or cyberwar. Notably, Peter Williams, an executive of US government contractor Trenchant, was sentenced this month to seven years in prison for selling hacking tools to the Russian zero-day broker Operation Zero from 2022 to 2025. Williams’ sentencing memo notes that Trenchant sold hacking tools to the US intelligence community as well as others in the “Five Eyes” group of English-speaking governments—the US, UK, Australia, Canada and New Zealand—though it's not clear what specific tools he sold or what devices they targeted.